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The entity : five centuries of secret Vatican espionage / Eric Frattini
Printed Book | 2010
Available at Santry Stacks (place request) (PB-335-738)
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Santry Stacks (place request) PB-335-738 IN
Assessment of glutamatergic synaptic transmission and plasticity in brain slices: relevance to bioelectronic approaches
Eric H. Chang;Samantha T. Carreiro;Stephen A. Frattini;Patricio T. Huerta
Academic Journal Academic Journal | Bioelectronic Medicine, Vol 5, Iss 1, Pp 1-12 (2019) TCD affiliated users click here for access
Abstract Background Glutamatergic neurons represent the largest neuronal class in the ... more
Assessment of glutamatergic synaptic transmission and plasticity in brain slices: relevance to bioelectronic approaches
Bioelectronic Medicine, Vol 5, Iss 1, Pp 1-12 (2019)
Abstract Background Glutamatergic neurons represent the largest neuronal class in the brain and are responsible for the bulk of excitatory synaptic transmission and plasticity. Abnormalities in glutamatergic neurons are linked to several brain disorders and their modulation represents a potential opportunity for emerging bioelectronic medicine (BEM) approaches. Here, we have used a set of electrophysiological assays to identify the effect of the pyrimidine nucleoside uridine on glutamatergic systems in ex vivo brain slices. An improved understanding of glutamatergic synaptic transmission and plasticity, through this type of examination, is critical to the development of potential neuromodulation strategies. Methods Ex vivo hippocampal slices (400 μm thick) were prepared from mouse brain. We recorded field excitatory postsynaptic potentials (fEPSP) in the CA1’s stratum radiatum by stimulation of the CA3 Schaeffer collateral/commissural axons. Uridine was applied at concentrations (3, 30, 300 μM) representing the physiological range present in brain tissue. Synaptic function was studied with input-output (I-O) functions, as well as paired-pulse facilitation (PPF). Synaptic plasticity was studied by applying tetanic stimulation to induce post-tetanic potentiation (PTP), short-term potentiation (STP) and long-term potentiation (LTP). Additionally, we determined whether uridine affected synaptic responses carried solely by n-methyl-d-aspartate receptors (NMDARs), particularly during the oxygen-glucose deprivation (OGD) paradigm. Results The presence of uridine altered glutamatergic synaptic transmission and plasticity. We found that uridine affected STP and LTP in a concentration-dependent manner. Low-dose uridine (3 μM) had no effect, but higher doses (30 and 300 μM) impaired STP and LTP. Moreover, uridine (300 μM) decreased NMDAR-mediated synaptic responses. Conversely, uridine (at all concentrations tested) had a negligible effect on PPF and basal synaptic transmission, which is mediated primarily by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). In addition, uridine (100 μM) exerted a protective effect when the hippocampal slices were challenged with OGD, a widely used model of cerebral ischemia. Conclusions Using a wide set of electrophysiological assays, we identify that uridine interacts with glutamatergic neurons to alter NMDAR-mediated responses, impair synaptic STP and LTP in a dose-dependent manner, and has a protective effect against OGD insult. This work outlines a strategy to identify deficits in glutamatergic mechanisms for signaling and plasticity that may be critical for targeting these same systems with BEM device-based approaches. To improve the efficacy of potential neuromodulation approaches for treating brain dysfunction, we need to improve our understanding of glutamatergic systems in the brain, including the effects of modulators such as uridine.

Subject terms:

Uridine - Nucleoside - LTP - Synaptic plasticity - Glutamate - NMDA - Medical technology - R855-855.5

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Directory of Open Access Journals
Transgenerational entrepreneurial family firms: An examination of the business model construct
Clinton, Eric;McAdam, Maura;Gamble, Jordan Robert
Academic Journal Academic Journal | In Journal of Business Research September 2018 90:269-285 TCD affiliated users click here for access
Holland-Frei Cancer Medicine / Robert C. Bast, Jr., Carlo M. Croce, William N. Hait, Waun Ki Hong, Donald W. Kufe, Martine Piccart-Gebhart, Raphael E. Pollock, Ralph R. Weichselbaum, Hongyang Wang, James F. Holland
e-Books (UK eLD) | 2017

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Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
Ally, Adrian;Balasundaram, Miruna;Carlsen, Rebecca;Chuah, Eric;Clarke, Aman...
Academic Journal Academic Journal | In Cell 15 June 2017 169(7):1327-1341 TCD affiliated users click here for access
Usefulness of a multiplying factor in predicting the final number of victims during a mass casualty incident
Olga Maurin;Michel Bignand;Daniel Jost;Stéphane Travers;Stéphane Raclot;Jul...
Electronic Resource Electronic Resource | European journal of emergency medicine, Volume 24:Number 5(2017). TCD affiliated users click here for access
Objective: Whenever a mass casualty incident (MCI) occurs, it is essential to anticipa... more
Usefulness of a multiplying factor in predicting the final number of victims during a mass casualty incident
European journal of emergency medicine, Volume 24:Number 5(2017).
Objective: Whenever a mass casualty incident (MCI) occurs, it is essential to anticipate the final number of victims to dispatch the adequate number of ambulances. In France, the custom is to multiply the initial number of prehospital victims by 2–4 to predict the final number. However, no one has yet validated this multiplying factor (MF) as a predictive tool. We aimed to build a statistical model to predict the final number of victims from their initial count. Methods: We observed retrospectively over 30 years of MCIs triggered in a large urban area. We considered three types of events: explosions, fires, and road traffic accidents. We collected the initial and final numbers of victims, with distinction between deaths, critical victims (T1), and delayed or minimal victims (T2–T3). The MF was calculated for each category of victims according to each type of event. Using a Poisson multivariate regression, we calculated the incidence risk ratio (IRR) of the final number of T1 as a function of the initial deaths and the initial T2–T3 counts, while controlling for potential confounding variables. Results: Sixty-eight MCIs were included. The final number of T1 increased with the initial incidence of deaths [IRR: 1.8 (1.4–2.2)], the initial number of T2–T3 being greater than 12 [IRR: 1.6 (1.3–2.1)], and the presence of one or more explosion [IRR: 1.4 (1.1–1.8)]. Conclusion: The MF seems to be an appealing decision-making tool to anticipate the need for ambulance resources. In explosive MCIs, we recommend multiplying T1 by 1.4 to estimate final count and the need for supplementary advanced life support teams.

Subject terms:

Europe - emergency medical services - mass casualty incident - triage - Emergency medicine - Medical emergencies - Emergency medical services - Emergencies - Emergency Medical Services - Emergency Medicine

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Electronic Legal Deposit
Solutions of the Yang–Baxter equation associated with a left brace
Bachiller, David;Cedó, Ferran;Jespers, Eric
Academic Journal Academic Journal | In Journal of Algebra 1 October 2016 463:80-102 TCD affiliated users click here for access
Vegetable-derived magnesium stearate functionality evaluation by DM3 approach
Haware, Rahul V.;Dave, Vivek S.;Kakarala, Bhavyasri;Delaney, Sean;Staton, S...
Academic Journal Academic Journal | In European Journal of Pharmaceutical Sciences 30 June 2016 89:115-124 TCD affiliated users click here for access
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
Anjum, Samreen;Arachchi, Harindra;Auman, J. Todd;Balasundaram, Miruna;Balu,...
Academic Journal Academic Journal | In Cell 28 January 2016 164(3):550-563 TCD affiliated users click here for access
The Entity is a primer in fast-and-shallow writing.
Jones, Arthur
Review Review | National Catholic Reporter. 2/6/2009, Vol. 45 Issue 8, p7a-7a. 2/3p. TCD affiliated users click here for access
The article reviews the book "The Entity: Five Centuries of Secret Vatican Espionage,"... more
The Entity is a primer in fast-and-shallow writing.
National Catholic Reporter. 2/6/2009, Vol. 45 Issue 8, p7a-7a. 2/3p.
The article reviews the book "The Entity: Five Centuries of Secret Vatican Espionage," by Eric Frattini, translated by Dick Cluster.

Subject terms:

ENTITY: Five Centuries of Secret Vatican Espionage, The (Book) - FRATTINI, Eric - NONFICTION - CATHOLIC Church government

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Academic Search Complete

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THE ENTITY: Five Centuries of Secret Vatican Espionage.
Review Review | Kirkus Reviews. 11/15/2008, Vol. 76 Issue 22, p1187-1187. 1/3p. TCD affiliated users click here for access
The article reviews the book "The Entity: Five Centuries of Secret Vatican Espionage,"... more
THE ENTITY: Five Centuries of Secret Vatican Espionage.
Kirkus Reviews. 11/15/2008, Vol. 76 Issue 22, p1187-1187. 1/3p.
The article reviews the book "The Entity: Five Centuries of Secret Vatican Espionage," by Eric Frattini.

Subject terms:

ENTITY: Five Centuries of Secret Vatican Espionage, The (Book) - FRATTINI, Eric - ESPIONAGE - NONFICTION

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Academic Search Complete

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A wide spectrum of EGFR mutations in glioblastoma is detected by a single clinical oncology targeted next-generation sequencing panel
Cimino, Patrick J.;Bredemeyer, Andy;Abel, Haley J.;Duncavage, Eric J.
Academic Journal Academic Journal | In Experimental and Molecular Pathology June 2015 98(3):568-573 TCD affiliated users click here for access
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